Antimicrobial Resistance: beta-Lactamase Genes Antimicrobial Resistance: beta-Lactamase Genes| FASTA sequence file: | beta-Lactamases |
| Phylogenetic trees: | beta-Lactamases Class A Class D Class C Class B |
See also: Lahey Clinic beta-lactamase database and NCBI beta-lactamase data resource
| Ambler class |
Bush-Jacoby group |
KO | Remark | |
| Serine | 2b | A | K18698(TEM) | |
| K18699(SHV) | ||||
| K18767(CTX-M) | ||||
| K18796(LAP) | ||||
| K18797(PER) | ||||
| K19097(VEB) | ||||
| K19317(BEL) | ||||
| 2f | K18768(KPC) | |||
| K18970(GES) | ||||
| K19316(IMI_SME) | IMI, SME | |||
| 2c | K18795(CARB-1) | CARB 1 2 3 6 11 12 | ||
| K19218(CARB-5) | CARB 5 8 10 14 16 (Acinetobacter, Psychrobacter) | |||
| K19217(CARB-17) | CARB 17 18 19 (Vibrio) | |||
| unclassified | K17836(penP) | |||
| 2d | D | K18790(OXA-1) | OXA 1 4 30 31 33 47 224 320 | |
| K18791(OXA-2) | OXA 2 3 15 21 32 34 36 53 141 161 210 226 415 | |||
| K19098(OXA-9) | OXA 9 | |||
| K18792(OXA-10) | OXA 7 10 11 13 14 16 17 19 28 35 56 74 101 142 145 147 183 233 240 246 251 256 454 | |||
| K19213(OXA-12) | OXA 12 (Aeromonas) | |||
| K21276(OXA-22) | OXA 22 443 (Ralstonia) | |||
| K18793(OXA-23) | OXA 23 27 49 73 102 103 105 133 146 165 166 167 168 169 170 171 225 239 366 398 422 423 435 481-483 (Acinetobacter) | |||
| K18971(OXA-24) | OXA 24 25 26 40 72 139 143 160 182 207 231 253 255 (Acinetobacter) | |||
| K19209(OXA-42) | OXA 42 43 57 59 (Burkholderia) | |||
| K18976(OXA-48) | OXA 48 54 162 163 181 199 204 232 244 245 247 370 405 484 | |||
| K18973(OXA-50) | OXA 50 (Pseudomonas) | |||
| K18794(OXA-51) | OXA 51 64-71 75-80 82-84 86-95 98-100 104 106-113 115-117 120 128 130-132 138 144 148-150 172-180 194-197 200-203 206 208 216 217 219 223 241 242 248-250 254 312-317 338 365 371 374-386 388-391 424-426 429-433 480 (Acinetobacter) | |||
| K18972(OXA-58) | OXA 58 96 97 164 397 420 (Acinetobacter) | |||
| K21277(OXA-60) | OXA 60 444 (Ralstonia) | |||
| K19210(OXA-61) | OXA 61 193 (Campylobacter) | |||
| K19211(OXA-62) | OXA 62 151-159 (Pandoraea) | |||
| K19212(OXA-63) | OXA 63 136 137 192 (Brachyspira) | |||
| K19319(OXA-134) | OXA 134 235 236 237 276 277 278 282 283 284 285 335 360 361 362 363 (Acinetobacter) | |||
| K19320(OXA-211) | OXA 211 212 280 281 309 333 334 (Acinetobacter) | |||
| K19318(OXA-213) | OXA 213 267 268 269 270 271 272 273 304 305 322 323 324 325 326 327 328 329 330 331 332 348 349 350 351 352 353 354 357 358 359 421 (Acinetobacter) | |||
| K19321(OXA-214) | OXA 214 215 264 265 (Acinetobacter) | |||
| K19322(OXA-228) | OXA 228 229 230 257 300 301 355 356 418 (Acinetobacter) | |||
| K21266(OXA-286) | OXA 286 287 288 291 292 293 302 303 306 307 (Acinetobacter) | |||
| unclassified | K17838(OXA) | |||
| 1 | C | K19095(CMY-1) | CMY 1 8 9 10 11 19, MOX | |
| K19101(FOX) | ||||
| K20320(PDC) | ||||
| K19214(ACC) | ||||
| K19100(DHA) | ||||
| K19096(CMY-2) | CMY others, CFE, LAT | |||
| K19215(ACT_MIR) | ACT, MIR | |||
| K20319(ADC) | ||||
| unclassified | K01467(ampC) | |||
| Metallo | 3 | B | K18782(IMP) | |
| K18781(VIM) | ||||
| K18780(NDM) | ||||
| K19099(GIM) | ||||
| K19216(IND) | (Chryseobacterium) | |||
| unclassified | K17837(bla2) | |||
| Class A | TEM | Temoneira (Greek patient) |
| SHV | Sulphydryl variable | |
| CTX-M | Cefotaxime | |
| PER | Pseudomonas extended-resistant | |
| VEB | Vietnam extended-spectrum beta-lactamase | |
| BEL | beta-Lactamase | |
| KPC | Klebsiella pneumoniae carbapenamase | |
| GES | Guiana extended-spectrum | |
| IMI | Imipenem | |
| SME | Serratia marcescens ESBL | |
| CARB | Carbenicillin | |
| Class D | OXA | Oxacillin |
| Class C (AmpC type) |
CMY | Cephamycin |
| CFE | Citrobacter freundii ESBL | |
| LAT | Latamoxef | |
| MOX | Moxalactam (Latamoxef) | |
| DHA | Dhahran Hospital in Saudi Arabia | |
| FOX | Cefoxitin | |
| ACC | Ambler class C | |
| ACT | AmpC type | |
| MIR | Miriam Hospital | |
| ADC | Acinetobacter derived cephalosporinase | |
| PDC | Pseudomonas derived cephalosporinase | |
| Class B (metallo) |
IMP | Imipenem-resistant Pseudomonas aeruginosa |
| VIM | Verona integron-encoded metallo-beta-lactamase | |
| NDM | New Delhi metallo-beta-lactamase | |
| IND | Chryseobacterium indologenes | |
| GIM | German imipenemase |
| Class | Drug group | Drug examples | Enzyme examples | Natural product (biosynthesis) | |
| beta-Lactamase sensitive penicillin (DG01778) |
Benzylpenicillin (DG00534) | Penicillinase | Penicillin (map00311) | ||
| beta-Lactamase resistant penicillin (DG01779) |
Meticillin (D02196) Oxacillin (DG00542) |
Oxacillinase | |||
| Extended spectrum penicillin (DG01780) |
Ampicillin (DG00517) Carbenicillin (DG00519) |
Carbenicillinase | |||
| beta-Lactamase inhibitor (DG01479) |
Sulbactam (DG00545) Tazobactam (DG00546) |
||||
| Clavulanic acid (DG01261) | Clavaminate (map00331) | ||||
| Carbapenem (DG01458) | Imipenem (DG01212) | Carbapenemase Imipenemase |
Carbapenem-3-carboxylate (map00332) |
||
| First-generation cephalosporin (DG01774) |
Cefaloridine (D01075) | Cephalosporinase | Cephamycin C (map00311) | ||
| Second-generation cephalosporin (DG01775) |
Cefoxitin (DG00557) | Cephamycinase | |||
| Flomoxef (DG00569) | |||||
| Loracarbef (DG00564) | |||||
| Third-generation cephalosporin (DG01776) |
Cefotaxime (DG00570) Ceftazidime (DG00571) |
Extended-spectrum beta-lactamase (ESBL) |
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| Latamoxef (DG00575) | |||||
| Fourth-generation cephalosporin (DG01777) |
Cefepime (DG01777) | ||||
| Monobactam (DG01454) | Aztreonam (DG00589) | Nocardicin A (map00261) | |||