KEGG image  Antimicrobial Resistance: Trimethoprim resistance genes

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Trimethoprim resistance KO

Mechanism KO Remark
Altered target (Dihydrofolate reductases) K18589 dfrA1/5/6/7/14/15/16/17/25/27/28/30/31/32
K19643 dfrA10
K18590 dfrA12/13/21/22/33
K19644 dfrA18
dfrA3
dfrA8
dfrA9
dfrA20
dfrA23
dfrA24
dfrA26
K18591 dfrD/G/K
K19645 dfrB1/2/3/4/5/6/8

Trimethoprim resistance genes

Name KEGG PubMed GenBank Species Length KO
dfrA1, dhfrIb ag:CAA25445 6308574 X00926 Escherichia coli 157 K18589
dfrA3 ag:AAA25550 2840679 J03306 Salmonella enterica 162
dfrA5 ag:CAA31356 3054482 X12868 157 K18589
dfrA6 ag:CAB06660 1941991 Z86002 Proteus mirabilis 157 K18589
dfrA7, dfrA17 ag:CAA41326 8195081 X58425 Escherichia coli 157 K18589
dfrA8 ag:AAA68493 7867952 U10186 Escherichia coli 169
dfrA9 ag:CAA40897 1659308 X57730 Escherichia coli 177
dfrA10 ag:AAA92749 1804022 L06418 Escherichia coli 187 K19643
dfrA12 ag:CAA79767 8392309 Z21672 Escherichia coli 165 K18590
dfrA13 ag:CAA90683 10639362 Z50802 Escherichia coli 165 K18590
dfrA14, dhfrIb ag:CAA90688 Z50805 Escherichia coli 157 K18589
dfrA15, dhfrXVb ag:CAB05887 9736538 Z83311 Escherichia coli 157 K18589
dfrA16 ag:AAK60186 12121950 AF174129 Escherichia coli 157 K18589
dfrA17 ag:BAD02331 15705645 AB126604 Salmonella enterica 157 K18589
dfrA18, dfrA19 ag:CAC81324 9835490 AJ310778 Salmonella enterica 189 K19644
dfrA20 ag:CAE53424 15616323 AJ605332 Pasteurella multocida 169
dfrA21, dfrxiii ag:AAS66087 15750057 AY552589 Salmonella enterica 165 K18590
dfrA22, dfr23 ag:CAF31623 15715715 AJ628423 Escherichia coli 165 K18590
dfrA23 ag:CAG34233 15728925 AJ746361 Salmonella enterica 186
dfrA24 ag:CAI99385 17307981 AJ972619 Escherichia coli 185
dfrA25 ag:ABB71176 16980698 DQ267940 Salmonella enterica 152 K18589
dfrA26 ag:CAL48457 17307981 AM403715 Escherichia coli 183
dfrA27 ag:ACD56152 19008256 EU675686 Escherichia coli 157 K18589
dfrA28 ag:CAT00035 FM877476 Aeromonas hydrophila 157 K18589
dfrA30, dhfrV ag:CAQ53849 21595893 AM997279 Klebsiella sp. MB45 157 K18589
dfrA31, dfr6 ag:BAD88719 AB200915 Vibrio cholerae 157 K18589
dfrA32 ag:ACZ52983 19921331 GU067642 Salmonella enterica 157 K18589
dfrA33 ag:CAX16467 20027306 FM957884 Staphylococcus haemolyticus 165 K18590
dfrD ag:CAA90486 8540692 Z50141 Staphylococcus haemolyticus 166 K18591
dfrG ag:BAE15963 16127079 AB205645 Staphylococcus aureus 165 K18591
dfrK ag:CAR62505 19015335 FM207105 Staphylococcus aureus 163 K18591
dfrB1, dfr2a ag:AAA82255 U36276 Escherichia coli 78 K19645
dfrB2, dfr2b ag:AAA72145 7022127 J01773 78 K19645
dfrB3, dfr2c ag:CAA51181 8195081 X72585 Enterobacter aerogenes 78 K19645
dfrB4, dfr2d ag:CAD22098 15715715 AJ429132 Escherichia coli 78 K19645
dfrB5, dfr2e ag:AAX46054 16048978 AY943084 Pseudomonas aeruginosa 78 K19645
dfrB6 ag:ABB72057 16870788 DQ274503 Salmonella enterica 78 K19645
dfrB8, dfrB7 ag:ADB54781 GU295656 Aeromonas hydrophila 82 K19645

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Last updated: November 9, 2015