KEGG image  Cytochrome P450 Interactions

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Inhibitors

CYP enzyme Strong (in vivo) Moderate (in vivo) Weak (in vivo)
CYP1A2 [hsa:1544] (DG01634) Ciprofloxacin (DG00617), Enoxacin (DG00619), Fluvoxamine (DG00946) Methoxsalen (D00139), Mexiletine (DG00197), Phenylpropanolamine (DG01041), Tiabendazole (D00372), Vemurafenib (D09996), Zileuton (D00414), Aciclovir (DG00406), Allopurinol (DG00779), Caffeine (DG00974), Cimetidine (DG00017), Daidzein (C10208), Disulfiram (D00131), Echinacea (E00764), Famotidine (D00318), Norfloxacin (DG00620), Propafenone (DG00200), Propafenone (DG00200), Terbinafine (DG00375), Ticlopidine(DG00156), Verapamil (DG00329)
CYP2B6 [hsa:1555] Clopidogrel (DG00155), Ticlopidine (DG00156), Prasugrel (D05597)
CYP2C8 [hsa:1558] (DG01641) Gemfibrozil (D00334) Fluvoxamine (DG00946), Ketoconazole (D00351), Trimethoprim (DG00595)
CYP2C9 [hsa:1559] (DG01643) Amiodarone (DG00204), Fluconazole (DG00371), Miconazole (DG00004), Oxandrolone (D00462) Capecitabine (D01223), Co-Trimoxazole (D00285), Etravirine (D04112), Fluvastatin (DG00354), Fluvoxamine (DG00946), Metronidazole (DG00006), Sulfinpyrazone (D00449), Tigecycline (D01079), Voriconazole (D00578), Zafirlukast (D00411)
CYP2C19 [hsa:1557] Fluconazole (DG00371), Fluvoxamine (DG00946), Ticlopidine (DG00156) Esomeprazole (DG00023), Fluoxetine (DG00942), Moclobemide (D02561) Allicin (C07600), Armodafinil (D03215), Carbamazepine (D00252), Cimetidine (DG00017), Etravirine (D04112), Somatropin (D02691), Felbamate (D00536), Ketoconazole (D00351)
CYP2D6 [hsa:1565] (DG01645) Bupropion (DG00957), Fluoxetine (DG00942), Paroxetine (DG00944), Quinidine (DG00192) Cinacalcet (DG00513), Duloxetine (DG00962), Terbinafine (DG00375) Amiodarone (DG00204), Celecoxib (D00567), Echinacea (E00764), Escitalopram (DG00947), Febuxostat (D01206), Gefitinib (D01977), Hydralazine (DG00261), Hydroxychloroquine (DG01015), Imatinib (DG00710), Methadone (DG00999), Pazopanib (D05380), Propafenone (DG00200), Ranitidine bismuth citrate (D05699), Ritonavir (D00427), Sertraline (DG00945), Telithromycin (D01078), Verapamil (DG00329), Vemurafenib (D09996)
CYP3A [hsa:1576 1577 1551] Boceprevir (D08876), Clarithromycin (DG00605), Conivaptan (DG00276), Grapefruit juice (E00839), Indinavir (DG00654), Itraconazole (D00350), Ketoconazole (D00351), Mibefradil (DG00328), Nefazodone (D00819), Nelfinavir (DG00655), Posaconazole (D02555), Ritonavir (D00427), Saquinavir (DG00653), Telaprevir (DG00953), Telithromycin (D01078), Voriconazole (D00578), Amprenavir (D00894), Aprepitant (DG00066), Atazanavir (DG00657), Ciprofloxacin (DG00617), Crizotinib (D09731), Diltiazem (DG00331), Erythromycin (DG00436), Fluconazole (DG00371), Fosamprenavir (DG00656), Grapefruit juice (E00839), Imatinib (DG00710), Verapamil (DG00329) Alprazolam (D00225), Amiodarone (DG00204), Amlodipine (DG00322), Atorvastatin (DG00355), Bicalutamide (D00961), Cilostazol (D01896), Cimetidine (DG00017), Ciclosporin (D00184), Fluoxetine (DG00942), Fluvoxamine (DG00946), Goldenseal (E00777), Isoniazid (DG00642), Lapatinib (DG00715), Nilotinib (DG00716), Pazopanib (D05380), Ranitidine (DG00018), Ranolazine (DG00247), Ticagrelor (D09017), Zileuton (D00414)

Inducers

CYP enzyme Strong (in vivo) Moderate (in vivo) Weak (in vivo) in vitro
CYP1A2 [hsa:1544] (DG01637) Montelukast (DG01066), Phenytoin (DG00846) Moricizine (DG00208), Omeprazole (DG00020), Phenobarbital (DG00845) Omeprazole (DG00020), Lansoprazol (D00355)
CYP2B6 [hsa:1555] Efavirenz (D00896), Rifampicin (DG00639) Nevirapine (D00435) Phenobarbital (DG00845)
CYP2C8 [hsa:1558] (DG01640) Rifampicin (DG00639) Rifampicin (DG00639)
CYP2C9 [hsa:1559] Carbamazepine (D00252), Rifampicin (DG00639) Aprepitant (DG00066), Bosentan (DG00266), Phenobarbital (DG00845),St. John's wort (E00784) Rifampicin (DG00639)
CYP2C19 [hsa:1557] Rifampicin (DG00639) Artemisinin (D02481) Rifampicin (DG00639)
CYP3A [hsa:1576 1577 1551] Avasimibe (D03012), Carbamazepine (D00252), Phenytoin (DG00846), Rifampicin (DG00639), St. John's wort (E00784) Bosentan (DG00266), Efavirenz (D00896), Etravirine (D04112), Modafinil (D01832), Nafcillin (DG00544) Amprenavir (D00894), Aprepitant (DG00066), Armodafinil (D03215), Clobazam (D01253), Pioglitazone (DG00117), Prednisone (DG00094), Rufinamide (D05775), Vemurafenib (D09996) Rifampicin (DG00639)

Substrates

CYP enzyme Sensitive substrates Substrates with narrow therapeutic range
CYP1A2 [hsa:1544] Alosetron (DG00046), Caffeine (DG00974), Duloxetine (DG00962), Melatonin (D08170), Ramelteon (D02689), Tacrine (DG00982), Tizanidine (D08611) Theophylline (DG01061), Tizanidine (D08611)
CYP2B6 [hsa:1555] Bupropion (DG01645), Efavirenz (D00896)
CYP2C8 [hsa:1558] Repaglinide (D00594) Paclitaxel (D00491)
CYP2C9 [hsa:1559] Celecoxib (D00567) Warfarin (DG00149), Phenytoin (DG00846)
CYP2C19 [hsa:1557] Clobazam (D01253), Lansoprazole (D00355), Omeprazole (DG00020), (S)-Mephenytoin (C20130) (S)-Mephenytoin (C20130)
CYP2D6 [hsa:1565] Atomoxetine (DG00970), Desipramine (DG00927), Dextromethorphan (DG01078), metoprolol(DG00313), Nebivolol (DG00319), Perphenazine (DG00875), Tolterodine (DG00480), Venlafaxine (DG00959) Thioridazine (DG00882), Pimozide (D00560)
CYP3A [hsa:1576 1577 1551] Alfentanil (DG00792), Aprepitant (DG00066), Budesonide (D00246), Buspirone (DG00913), Conivaptan (DG00276), Darifenacin (DG00482), Darunavir (DG00659), Dasatinib (DG00714), Dronedarone (DG00207), Eletriptan (DG00840), Eplerenone (D01115), Everolimus (D02714), Felodipine (D00319), Indinavir (DG00654), Fluticasone (DG00420), Lopinavir (D01425), Lovastatin (D00359), Lurasidone hydrochloride (D04820), Maraviroc (D06670), Midazolam (DG00920), Nisoldipine (D00618), Quetiapine (DG00899), Saquinavir (DG00653), Sildenafil (DG00484), Simvastatin (D00434), Sirolimus (D00753), Tolvaptan (D01213), Tipranavir (DG00658), Triazolam (D00387), Ticagrelor (D09017), Vardenafil (DG00487) Alfentanil (DG00792), Astemizole (D00234), Cisapride (DG00056), Cyclosporine (D00184), Dihydroergotamine (DG00833), Ergotamine (DG00834), Fentanyl (DG00791), Pimozide (D00560), Quinidine (DG00192), Sirolimus (D00753), Tacrolimus (DG00439), Terfenadine (D00521)

According to FDA Guidance on Drug Interactions and Table of Substrates, Inhibitors and Inducers
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Last updated: March 12, 2015