Antifungals Antifungals| Class | Generic name | ATC | KEGG | Products (USA) | Products (Japan) | Indications | Species | |
| Cell membrane function inhibitor | Polyene macrolide | Amphotericin B | J02AA01 | D00203 | AMBISOME AMPHOTEC |
AMBISOME | Fungal infection Invasive aspergillosis |
Cryptococcus, Aspergillus, Candida |
| Nystatin | D01AA01 A07AA02 G01AA01 | D00202 | NYSTATIN | NYSTATIN | Cutaneous or mucocutaneous mycotic infections | Candida albicans, Candida species | ||
| Natamycin | D01AA02 A01AB10 A07AA03 G01AA02 S01AA10 | D00884 | NATACYN | PIMARICIN | Fungal blepharitis, conjunctivitis, and keratitis | Fusarium solani | ||
| Pyridone derivatives | Ciclopirox | D01AE14 G01AX12 | D03488 D01364 | LOPROX PENLAC |
Seborrheic dermatitis Onychomycosis Dermal infections |
Malassezia, Trichophyton, Candida | ||
| Combination of macrolide | Nystatin - triamcinolone | D07CB01 | D10299 | NYSTATIN AND TRIAMCINOLONE | Cutaneous candidiasis | Candida | ||
| Mitosis inhibitor | Penicillium-derived | Griseofulvin | D01AA08 D01BA01 | D00209 | GRIS-PEG | Ringworm infections | Trichophyton | |
| Ergosterol biosynthesis inhibitor | Imidazole | Miconazole | J02AB01 D01AC02 A01AB09 A07AC01 G01AF04 S02AA13 | D00416 | ORAVIG | FLORID | Oropharyngeal candidiasis (OPC) | Candida |
| Ketoconazole | J02AB02 D01AC08 G01AF11 | D00351 | NIZORAL | NIZORAL XOLEGEL |
Tinea (pityriasis) versicolor Seborrheic dermatitis |
Malassezia | ||
| Clotrimazole | D01AC01 A01AB18 G01AF02 | D00282 | CLOTRIMAZOLE | EMPECID | Oropharyngeal candidiasis Candidiasis (tinea versicolor) |
Candida, Malassezia | ||
| Econazole | D01AC03 G01AF05 | D00881 | ECOZA | PALAVALE | Interdigital tinea pedis, tinea cruris, tinea corporis | Trichophyton | ||
| Isoconazole | D01AC05 G01AF07 | D01480 | ADESTAN | Tinea, candidiasis, tinea versicolor Vulvovaginitis |
Trichophyton, Candida, Malassezia | |||
| Sulconazole | D01AC09 | D00886 | EXELDERM | EXELDERM | Tinea pedis, tinea cruris, tinea corporis, tinea versicolor | Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis | ||
| Bifonazole | D01AC10 | D01775 | MYCOSPOR | Tinea, candidiasis, tinea versicolor | Trichophyton, Candida, Malassezia | |||
| Oxiconazole | D01AC11 G01AF17 | D00885 | OXISTAT | OKINAZOLE | Dermal infections (tinea pedis, tinea cruris, tinea corporis) tinea (pityriasis) versicolor |
Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum Malassezia furfur |
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| Sertaconazole | D01AC14 G01AF19 | D08510 | ERTACZO | Interdigital tinea pedis | Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum | |||
| Butoconazole | G01AF15 | D00880 | GYNAZOLE 1 | Vulvovaginal candidiasis | Candida | |||
| Lanoconazole | D01092 | ASTAT | Tinea, candidiasis, tinea versicolor | Trichophyton, Candida, Malassezia | ||||
| Neticonazole | D01620 | ATOLANT | Tinea, candidiasis, tinea versicolor | Trichophyton, Candida, Malassezia | ||||
| Luliconazole | D01980 | LUZU | LULICON | Interdigital tinea pedis, tinea cruris, tinea corporis | Trichophyton rubrum, Epidermophyton floccosum | |||
| Triazole (DG01523) | Fluconazole | J02AC01 D01AC15 | D00322 | DIFLUCAN | DIFLUCAN | Vaginal candidiasis, Oropharyngeal and esophageal candidiasis, Cryptococcal meningitis | Candida, Cryptococcus | |
| Fosfluconazole | D01429 | PRODIF | Candidiasis, Cryptococcosis | Candida, Cryptococcus | ||||
| Itraconazole | J02AC02 | D00350 | SPORANOX | ITRIZOLE | Fungal infections (blastomycosis, histoplasmosis, aspergillosis) Onychomycosis Oropharyngeal and esophageal candidiasis |
Blastomyces dermatitidis, Histoplasma capsulatum, Aspergillus Trichophyton Candida |
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| Voriconazole | J02AC03 | D00578 | VFEND | VFEND | Fungal infections (invasive aspergillosis, candida infections, fusarium infections) | Aspergillus, Candida, Fusarium | ||
| Posaconazole | J02AC04 | D02555 | NOXAFIL | Invasive aspergillus, candida infections (oropharyngeal candidiasis) | Aspergillus, Candida | |||
| Terconazole | G01AG02 | D00888 | TERAZOL | Vulvovaginal candidiasis (moniliasis) | Candida | |||
| Efinaconazole | D10021 | JUBLIA | CLENAFIN | Onychomycosis | Trichophyton rubrum, Trichophyton mentagrophytes | |||
| Allylamine | Terbinafine | D01AE15 D01BA02 | D02219 | LAMISIL | LAMISIL | Onychomycosis | Dermatophytes | |
| Naftifine | D01AE22 | D00883 | NAFTIN | Interdigital tinea pedis, tinea cruris, and tinea corporis | Trichophyton rubrum | |||
| Morpholine | Amorolfine | D01AE16 | D01720 | PEKIRON | Dermatomycosis (tinea, cutaneous candidiasis, tinea versicolor) | Trichophyton, Candida, Malassezia | ||
| Thiocarbamate | Tolnaftate | D01AE18 | D00381 | HI-ALARZIN | Trichophytia pompholyciformis, marginated eczema, trichophytia maculovesiculosa, tinea versicolor | Trichophyton, Malassezia | ||
| Liranaftate | D01550 | ZEFNART | Tinea | Trichophyton | ||||
| Benzylamine | Butenafine | D01AE23 | D01093 | MENTAX | VOLLEY MENTAX |
Tinea, tinea versicolor | Trichophyton, Malassezia | |
| Combination of azole | Clotrimazole - betamethasone | D07CC01 | D10300 | LOTRISONE | Tinea pedis, tinea cruris, tinea corporis | Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum | ||
| Nucleic acid synthesis inhibitor | Fluoropyrimidine | Flucytosine | J02AX01 D01AE21 | D00323 | ANCOBON | ANCOTIL | Candida infections, Cryptococcus infections | Candida, Cryptococcus |
| Folic acid biosynthesis inhibitor | Sulfonamide | Sulfanilamide | J01EB06 D06BA05 | D08543 | AVC | Vulvovaginitis | Candida albicans | |
| Combination of sulfonamide | Trimethoprim-sulfamethoxazole | J01EE01 | D00285 | BACTRIM SULFATRIM |
BACTAR BACTRAMIN |
Carinii pneumonia, Pneumocystis pneumonia | Pneumocystis carinii, Pneumocystis jirovecii | |
| Cell wall biosyntehsis inhibitor | Echinocandin | Caspofungin | J02AX04 | D02501 | CANCIDAS | CANCIDAS | Fungal infections (Candida infections, esophageal candidiasis, invasive aspergillosis) | Candida, Aspergillus |
| Micafungin | J02AX05 | D02465 | MYCAMINE | FUNGUARD | Candida infections | Candida | ||
| Anidulafungin | J02AX06 | D03211 | ERAXIS | Candida Infections | Candida | |||
| Other | Salicylic acid | D01AE12 S01BC08 | D00097 | SALICYLIC ACID | SALICYLIC ACID | Hyperkeratotic skin disorders | Torichophyton, Malassezia | |
| Selenium sulfide | D01AE13 D11AC03 | D05815 | SELENIUM SULFIDE | Tinea versicolor, seborrheic dermatitis of the scalp, and dandruff | Malassezia | |||
| Category | Title | Comment |
| Metabolic pathway map | Steroid biosynthesis | Target molecules in ergosterol biosynthesis pathway |
| Drug structure map | Antifungal agents |