ANNOUNCING PFAM RELEASE 4.1 =========================== Pfam is a collection of protein domain family alignments which were constructed semi-automatically using profile hidden Markov models. Pfam families contain functional annotation and cross-references to other databases. Query sequences can be searched against the Pfam library of profile hidden Markov models at the web sites below. Pfam 4.1 contains 1488 families. 57% of proteins in SWISSPROT 37 and TrEMBL 9 have at least one match to a Pfam family. For interactive access and searching see URLs http://www.sanger.ac.uk/Software/Pfam/ http://pfam.wustl.edu/ http://kisac.cgr.ki.se/Pfam/ The release is also available in flat file by anonymous ftp: ftp://ftp.sanger.ac.uk/pub/databases/Pfam/ ftp://ftp.genetics.wustl.edu/pub/Pfam/ The Pfam HMM library is compatible with HMMER2 software, available from http://hmmer.wustl.edu/ and also the Wise2 software, available from http://www.sanger.ac.uk/Software/Wise2/ ___________________ The Pfam consortium 99-07